The Science Behind Medical Marijuana and Its Effects on Epileptic Seizures

The Science Behind Medical Marijuana and Its Effects on Epileptic Seizures

Medical Marijuana has garnered significant attention for its benefits in treating epilepsy and seizures. The science behind its effects on epileptic seizures is both complex and promising, involving multiple mechanisms of action within the brain.

Medical Marijuana exhibits neuroprotective properties, meaning it can protect nerve cells against damage, degeneration, or impairment of function in conditions like epilepsy, where excessive neuronal activity can lead to damage.

The endocannabinoid system (ECS) plays a significant role in regulating physiological processes, including mood, pain sensation, appetite, and memory. Medical Marijuana interacts with the ECS by inhibiting the breakdown of the endocannabinoid anandamide, a neurotransmitter that reduces pain and increases feelings of well-being. Higher levels of anandamide can reduce seizure activity.

The other endocannabinoid, 2-AG activates CB1 receptors and is involved in physiological functions, such as emotion, cognition, energy balance, pain sensation, and neuroinflammation. 

Medical Marijuana has been shown to have anti-inflammatory properties. Inflammation in the brain is thought to contribute to the development and persistence of seizures. By reducing inflammation, Medical Marijuana helps to control seizures. It also affects the levels of neurotransmitters in the brain, such as glutamate and GABA (gamma-aminobutyric acid). Glutamate is associated with increased seizure activity, while GABA acts as an inhibitory neurotransmitter, helping to calm neuronal activity. CBD’s ability to reduce glutamate levels and enhance GABA activity can help to reduce seizures.

The most compelling evidence of the effectiveness of Medical Marijuana in treating epilepsy comes from clinical trials. These studies have led to the approval of Epidiolex by the U.S. Food and Drug Administration (FDA) for the treatment of seizures associated with two rare and severe forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome.

The science behind medical marijuana’s effects on epileptic seizures highlights the potential in offering an alternative treatment for patients with difficult-to-control seizures. Ongoing research and clinical trials will continue to elucidate the mechanisms by which cannabinoids exert their effects and to identify which patients may benefit most from this treatment option.

We offer no-risk consultations, so you can begin the process whether or not you’re entirely sure you qualify for Medical Marijuana. Our double board-certified doctor and compassionate staff provide fast and affordable evaluations and Medical Marijuana ID card certifications in Florida.